Chemotherapy drugs have different types, many that are used in the treatment of mesothelioma. One of the oldest drugs used to treat cancer are alkylating agents. This agent is toxic to cells, is very reactive, and can give an alkyl group to another compound, such as a cancer cell. Alkylating agents damage DNA preventing a cancer cell from reproducing.

Because alkylating agents are used for lung cancer, they are often used as part of your pleural mesothelioma treatment. The various types include:

• Nitrogen mustards (mechlorethamine, chlorambucil, cyclophosphamide, ifosfamide, and malphalan)
• Nitrosoureas (streptozocin, carmustine, and lomustine)
• Alkyl sulfonates (busulfan)
• Triazines (dacarbazine and temozolomide)
• Ethylenimines (thiotepa and altretamine)

As is common with chemotherapy drugs, alkylating agents are often given in combination with other drugs, such as Alimta, an antifolate. Because of the way the agents damage DNA, they can cause long-term damage to bone marrow, and in rare cases, acute leukemia.

Chemotherapy drugs often have side effects, such as nausea, vomiting, fatigue, weight loss, and hair loss. You should discuss the details of your mesothelioma treatment with your doctor, particularly with regard to any medications you are taking, or any health issues you may have.

We understand you have a lot of questions that require answers in a short period of time. Sometimes it would be nice to speak with someone who can help you sort out the details. Feel free to contact one of our mesothelioma family advocates to ask questions and learn about your options.

Tags: mesothelioma, mesothelioma treatment

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